Clinical Research Trials in Primary Care

Mayford House Surgery actively supports clinical research trials in primary care. We believe that this is a great opportunity for our patients who may be eligible for studies to help shape the future of medicine. Taking part in research studies demonstrates Mayford House Surgery’s commitment to quality improvement.

There are several types of studies that we may be involved in. For some studies we may send out letters or SMS messages to invite patients to participate depending on if they meet certain criteria. For others we rely on patients identifying themselves from publicity around the surgery.

2025/2026 Research Update

This year we have developed our research team and are working more collaboratively with Mowbray House Surgery. This enables us to be part of more interventional and commercial studies (these are run by pharmaceutical or drug companies) which we feel is important to be able to offer our patients with the aim of improving individuals’ health but also health care for the future. We are very proud to share the news that we have also recruited our first patient to our first commercial study.

Recently completed studies:

HipDys: Evaluated the aid of diagnosis for babies born with an abnormal ball and socket joint of the hip in general practice.

STREAM: Looked at whether nutrition screen and treat policies for primary care are effective among an at risk free living older population in primary care.

PHILM-GP: Assessed how physical illness is diagnosed for people with mental health conditions in general practice.

iiD3: Infectious Intestinal Disease (Study 3) – looked at patients 18-years and over who had either diarrhoea or vomiting and did not know the reason why they had it.

Current studies:

COAT: a trial looking at the best use of oral antibiotics in patients with leg cellulitis.

DURATION UTI: this is a randomised control (this means patients are allocated at random to different treatments) trial looking at the impact of different length antibiotic courses on resistance and the effectiveness of treatment of Urinary Tract Infections (UTI) in adult women.

OPTIMISE2: this aims to establish whether deprescribing common drugs that lower blood pressure is safe or effective in patients over the age of 75 in the longer term (a year or more).

THARROS: a clinical study looking at whether treatments for Chronic Obstructive Pulmonary Disease (COPD) may help prevent COPD flare-ups and serious heart attacks.

BI EASi-PROTKTTM: is evaluating how effective and safe different combinations of medicines are for patients with type 2 diabetes, arterial hypertension (high blood pressure) and established cardiovascular disease (heart related issues).

BRISMED: this project assesses long term medication reviews, by implementing a review toolkit to GP surgeries for one year, with the aim of improving how medicines are used and the number of medicines prescribed to patients.

PRIMARY BREATHE: this is a feasibility (looking at whether it is appropriate to study further) study looking at how effective interventions are versus routine care for patients with chronic breathlessness.

3i-O: is looking at the impacts of health inequalities in patients being potentially overprescribed addictive painkillers and antibiotics in primary care.

TAKE-A-TEST: ongoing testing of patients who have cold/flu/coughing symptoms with the aim of looking at numbers of cases of viruses such as COVID-19, flu, Respiratory Syncytial Virus (RSV).